Trifluoroacetic acid → [6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt
Reaktionsgleichung
C([O:5][C:6](=[O:22])[CH2:7][O:8][C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:13][CH:14]=1)(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>>[F:26][C:25]([F:28])([F:27])[C:23]([OH:29])=[O:24].[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:12]1[N:11]=[CH:10][C:9]([O:8][CH2:7][C:6]([OH:22])=[O:5])=[CH:14][CH:13]=1Komponenten
3
Versuchsvorschrift
300 mg (0.99 mmol) of [6-(2-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid tert-butyl ester in 10 ml of 90% aqueous TFA were allowed to stand at room temperature for 1.5 h. The mixture was concentrated and lyophilized. Yield: 286 mg.
Aufarbeitung
- concentrationThe mixture was concentrated