Hydrochloric Acid → 2-Amino-4,4-difluorobutanoic acid hydrochloride

HRID 19323Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 19323
C([O:3][C:4](=[O:19])[C:5]([NH:15]C(=O)C)([CH2:11][CH:12]([F:14])[F:13])C(OCC)=O)C.[ClH:20]>>[ClH:20].[NH2:15][CH:5]([CH2:11][CH:12]([F:14])[F:13])[C:4]([OH:19])=[O:3]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 17749984Diethyl 2-acetamido-2-(2,2-difluoroethyl)malonate

Produkt 1

HCID 470033322-Amino-4,4-difluorobutanoic acid hydrochlorideAusbeute 97 %

Versuchsvorschrift

In a flask was placed 2-acetylamino-2-(2,2-difluoro-ethyl)-malonic acid diethyl ester (8.94 g, 31.78 mmol) and 6N aqueous hydrochloric acid (140 mL). This mixture was refluxed overnight. After this time, the mixture was cooled to room temperature and extracted with diethyl ether (100 mL) the aqueous layer was concentrated in vacuo, azeotroped with acetonitrile and dried under high vacuum to afford 2-amino-4,4-difluoro-butyric acid hydrochloride salt (5.39 g, 97%) as a cream colored solid.

Aufarbeitung

  1. customIn a flask was placed
  2. temperatureThis mixture was refluxed overnight
  3. extractionextracted with diethyl ether (100 mL) the aqueous layer
  4. concentrationwas concentrated in vacuo
  5. customazeotroped with acetonitrile
  6. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c9fda19b50b74a45a68557364533658c
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741327B2

Notizen zur Reaktion

Wird geladen…