Thionyl Chloride → 3-(4-Methoxyphenyl)-2-phenylpropionyl chloride

HRID 1935735

Reaktionsgleichung

Reaktionsgleichung von HRID 1935735
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1.S(Cl)([Cl:22])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([Cl:22])=[O:12])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 977393-(4-Methoxyphenyl)-2-phenylpropionic acid

Produkt 1

HCID 111403233-(4-Methoxyphenyl)-2-phenylpropionyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-(4-Methoxyphenyl)-2-phenylpropanoic acid (12.5 g, 0.049 mol) was converted to its acid chloride by treatment with thionyl chloride (8.2 ml) in dry dichloromethane (75 ml) at 40° C. Excess thionyl chloride and dichloromethane were evaporated off. The crude product was used in the next step without purification.

Aufarbeitung

  1. customExcess thionyl chloride and dichloromethane were evaporated off
  2. customThe crude product was used in the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-8330fac80b4f466ab997698fb37b3886
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06388090B2

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