2-Methyl-6-(propan-2-yl)benzoyl chloride → HCID 69716544, Verbindung
Reaktionsgleichung
C[O:2][C:3](=[O:26])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:25])[N:15]([CH3:24])[C:16]([CH3:23])=[CH:17][C:18]=2[C:19]([F:22])([F:21])[F:20])=[CH:9][CH:8]=1)[NH2:5].[CH3:27][CH:28]([C:30]1[CH:38]=[CH:37][CH:36]=[C:35]([CH3:39])[C:31]=1[C:32](Cl)=[O:33])[CH3:29]>>[CH3:29][CH:28]([C:30]1[CH:38]=[CH:37][CH:36]=[C:35]([CH3:39])[C:31]=1[C:32]([NH:5][C@H:4]([C:3]([OH:2])=[O:26])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:14](=[O:25])[N:15]([CH3:24])[C:16]([CH3:23])=[CH:17][C:18]=2[C:19]([F:22])([F:20])[F:21])=[CH:9][CH:8]=1)=[O:33])[CH3:27]Komponenten
3
Versuchsvorschrift
N-[[2-(1-methylethyl)-6-methylphenyl]carbonyl]-4-[ 1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine was prepared from 4-[1,6-dimethyl-4-(trifluoromethyl)-2-oxo-3-pyridinyl]-L-phenylalanine methyl ester and 2-(1-methylethyl)-6-methylbenzoyl chloride using the general procedures described in example 33. ES-HRMS m/e calcd for C28H29F3N2O4 (M+Na) 537.1972, found 537.1977.
Quellen und Nachweise
- ORD-Eintrag
- ord-d483afb105024960bc0670d17952265f
- Quelldatensatz
- uspto-grants-2002_05