Sodium Hydroxide → sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate

HRID 1936972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1936972
C([O:3][C:4]([CH2:6][O:7][C:8]1[C:13]2[CH2:14][CH2:15][CH2:16][CH:17]([NH:19][CH2:20][C@H:21]([OH:30])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][C:12]=2[CH:11]=[CH:10][CH:9]=1)=[O:5])C.[OH-].[Na+:32]>CO>[OH:30][C@H:21]([CH2:22][O:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:20][NH:19][CH:17]1[CH2:16][CH2:15][CH2:14][C:13]2[C:8]([O:7][CH2:6][C:4]([O-:5])=[O:3])=[CH:9][CH:10]=[CH:11][C:12]=2[CH2:18]1.[Na+:32]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 70131462(2S)-1-[(1-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol

Produkt 1

HCID 86584188sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of (2S)-1-[(1-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol (103 mg) in methanol (5.0 ml) and 0.1N sodium hydroxide aqueous solution (2.5 ml) was stirred for 22 hours and evaporated in vacuo. The residue was triturated in diethyl ether and the precipitated powder was collected by filtration to afford sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate (98 mg) as a pale yellow powder.

Aufarbeitung

  1. customevaporated in vacuo
  2. customThe residue was triturated in diethyl ether
  3. filtrationthe precipitated powder was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ca2fdbd3cfa04b9db071205cd19d7277
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06391915B2

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