Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol dihydrochloride

HRID 1937419

Reaktionsgleichung

Reaktionsgleichung von HRID 1937419
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:4].[ClH:30]>C(O)C.C(OCC)(=O)C>[ClH:30].[ClH:30].[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH3:4]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 54071300HCID 54071300, Verbindung

Produkt 1

HCID 119720442-(Piperazin-1-yl)propan-1-ol dihydrochlorideAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1-(1-Hydroxy-2-propyl)-2-triphenylmethylpiperazine (1.69 g) obtained in step 2 was dissolved in ethanol (20 ml), and a 4 mol/l hydrogen chloride solution in ethyl acetate (10 ml) was dropwise added thereto. The mixture was stirred at room temperature for 10 minutes. The solvent was distilled off under reduced pressure, the residue was suspended in ethyl ether, and the precipitated crystals were collected by filtration to give Compound L (840 mg, 89%).

Aufarbeitung

  1. distillationThe solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c8601b29fb4040a69dddd3603f032fcd
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06395738B1

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