4-Piperidinecarboxamide → 1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]piperidine-4-carboxamide

HRID 1937666Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1937666
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:2]1.Cl[CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH3:27])=[C:20]([O:28][CH3:29])[CH:19]=2)[CH:13]=1>>[CH3:25][O:24][C:22]1[CH:23]=[C:18]([C:14]2[CH:13]=[C:12]([CH2:11][N:1]3[CH2:6][CH2:5][CH:4]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:2]3)[CH:17]=[CH:16][N:15]=2)[CH:19]=[C:20]([O:28][CH3:29])[C:21]=1[O:26][CH3:27]

Komponenten

3

Edukt 2

HCID 37724-PiperidinecarboxamideHCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine

Produkt 1

HCID 225579821-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl]piperidine-4-carboxamide

Versuchsvorschrift

Piperidine-4-carboxamide (385 mg) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (881 mg) were condensed by the same method as described in Example 2 to give the title compound as white needles.

Aufarbeitung

  1. customcondensed by the same method

Quellen und Nachweise

ORD-Eintrag
ord-8f43a8dc0bb74ac8836cdbe7f03acea0
Quelldatensatz
uspto-grants-2002_05
Patentnummer
US06395753B1

Notizen zur Reaktion

Wird geladen…