1-[4-(N,N-diethylaminosulfonyl)phenyl]-4,4,4-trifluoro-3-hydroxy-3-methylbut-1-yne → 1-[4-(N,N-Diethylaminosulfonyl)phenyl]-4,4,4-trifluoro-3-hydroxy-3-methyl-trans-but-1-ene
Reaktionsgleichung
[CH2:1]([N:3]([CH2:22][CH3:23])[S:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][C:15]([OH:21])([CH3:20])[C:16]([F:19])([F:18])[F:17])=[CH:9][CH:8]=1)(=[O:6])=[O:5])[CH3:2].FC(F)(F)C(O)(C)C#CC1C=CC(S(N2CCCC2)(=O)=O)=CC=1>>[CH2:22]([N:3]([CH2:1][CH3:2])[S:4]([C:7]1[CH:8]=[CH:9][C:10](/[CH:13]=[CH:14]/[C:15]([OH:21])([CH3:20])[C:16]([F:17])([F:18])[F:19])=[CH:11][CH:12]=1)(=[O:5])=[O:6])[CH3:23]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
Using a procedure similar to that described in Example 11, but substituting 1-[4-(N,N-diethylaminosulfonyl)phenyl]-4,4,4-trifluoro-3-hydroxy-3-methylbut-1-yne for the 4,4,4-trifluoro-3-hydroxy-3-methyl-1-[4-(1-pyrrolidinylsulfonyl)phenyl]but-1-yne used therein, the title compound was prepared; mp 112.1°-117.2° C.; MS: m/z=352(M+1). Analysis for C15 H20F3NO3S: Calculated: C, 51.27; H, 5.74; N, 3.99. Found: C, 51.17; H, 5.96; N, 3.87.