3-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline → 3-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

HRID 1938336Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1938336
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:24])[F:23])[CH:8]=2)([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:23])[F:24])[CH:8]=2

Komponenten

4

Edukt 1

HCID 214693273-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline

Produkt 1

HCID 214693313-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (30 mL) was suspended 3-nitro-7-(2-trifluoromethylbenzyloxy)quinoline (600 mg, 1.72 mmol.), and to the suspension was added platinum oxide (72 mg). Then, catalytic reduction was performed for 3 hours. After the completion of reaction was confirmed, the reaction mixture was filtered over Celite®, and the filtrate was placed under reduced pressure to leave the desired compound as brown oil in the quantitative yield.

Aufarbeitung

  1. customAfter the completion of reaction
  2. filtrationthe reaction mixture was filtered over Celite®

Quellen und Nachweise

ORD-Eintrag
ord-ec5422ec689e43a8bdbf528a60d38702
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05693651

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