Ammonia → HCID 21469426, Verbindung

HRID 1938362Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1938362
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][CH:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([C:31](O)=[O:32])[CH:29]=3)[NH:24][CH:23]=2)[CH2:18][CH2:17]1.CS([O-])(=O)=O.ClC1C=CC=C[N+:41]=1C.N>CN1CCCC1=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][CH2:14][CH2:15][N:16]1[CH2:17][CH2:18][CH:19]([C:22]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([C:31]([NH2:41])=[O:32])[CH:29]=3)[NH:24][CH:23]=2)[CH2:20][CH2:21]1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 9834448HCID 9834448, VerbindungHCID 21469431HCID 21469431, Verbindung

Produkt 1

HCID 21469426HCID 21469426, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

2.1 g of 3-[1-(4-(5-methoxyindol-3-yl)butyl)-4-piperidyl]indole-5-carboxylic acid are suspended in 100 ml of N-methylpyrrolidone. 3.2 g of 2-chloro-1-methylpyridinium methanesulfonate are then added and the mixture is stirred at room temperature for 12 hours. Dried NH3 gas is passed into the resulting solution until it is saturated and it is stirred again for 10 hours. Working-up in a conventional manner gives 3-[1-(4-(5-methoxyindol-3-yl)butyl)-4-piperidyl]indole-5-carboxamide.

Aufarbeitung

  1. stirringit is stirred again for 10 hours

Quellen und Nachweise

ORD-Eintrag
ord-a9284366a8844ca7b167fbe242469312
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05693655

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