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Hydrochloric Acid → 6-[5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoic acid

HRID 1938509
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1938509
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([C:21]2[NH:22][C:23](=[O:30])[C:24]([CH:27]([CH3:29])[CH3:28])([CH3:26])[N:25]=2)=[C:7]([CH:20]=1)[C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]C)=[O:17])=[O:9])[CH3:2].[OH-].[Na+].Cl>O1CCCC1>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([C:21]2[NH:22][C:23](=[O:30])[C:24]([CH:27]([CH3:29])[CH3:28])([CH3:26])[N:25]=2)=[C:7]([CH:20]=1)[C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:9])[CH3:2]
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Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22450188Methyl 6-[5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoate

Produkt 1

HCID 189772396-[5-Ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028Tetrahydrofuran
Lösungsmittel

Versuchsvorschrift

A stirred solution of methyl 6-[5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinamido]hexanoate (5.14 g, 12.35 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (15 mL). The resulting mixture is stirred at room temperature for 24 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is cooled with an ice bath and acidified with concentrated hydrochloric acid. The resulting precipitate is isolated by vacuum filtration and washed with water to give the title product as a white solid, mp 76°-81° C.

Aufarbeitung

  1. waitAfter this period
  2. concentrationthe reaction mixture is concentrated in vacuo
  3. customto obtain a residue
  4. temperatureThe residue is cooled with an ice bath
  5. customThe resulting precipitate is isolated by vacuum filtration
  6. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-ef7db4d8cd6c4e9fae62a074908f2af0
Quelldatensatz
uspto-grants-1997_12
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05693658

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