Ethyl 4,4,4-trifluoro-3-oxo-2-phenylbutanoate → 6-Trifluoromethyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1939147Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1939147
[F:1][C:2]([F:18])([F:17])[C:3]([CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]CC)=O)=[O:4].[CH2:19]=[N:20][C:21]([CH3:31])([C:23]1[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([Cl:30])[CH:24]=1)[CH3:22]>C1(C)C(C)=CC=CC=1>[F:18][C:2]([F:1])([F:17])[C:3]1[O:4][CH2:19][N:20]([C:21]([CH3:31])([C:23]2[CH:24]=[C:25]([Cl:30])[CH:26]=[C:27]([Cl:29])[CH:28]=2)[CH3:22])[C:6](=[O:8])[C:5]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 2

HCID 13913997Ethyl 4,4,4-trifluoro-3-oxo-2-phenylbutanoateHCID 21223286N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

Produkt 1

HCID 212232766-Trifluoromethyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-oneAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

Ethyl 2-trifluoroacetyl-2-phenylacetate (1.30 g) and N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine (1.19 g) were mixed, and xylene (10 ml) was added thereto. The mixture was allowed to react by refluxing for 30 minutes. The solvent was removed by evaporation, and the crude product was recrystallized from a mixture of hexane and ethyl acetate to afford the captioned compound (1.80 g, yield 84%).

Aufarbeitung

  1. customto react
  2. temperatureby refluxing for 30 minutes
  3. customThe solvent was removed by evaporation
  4. customthe crude product was recrystallized from a mixture of hexane and ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-23118503df7048059f2b101b339f46a4
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05696054

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