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Hydrochloric Acid → 9-(N,N-Dimethylaminomethyl)-2-(2-fluoropenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one monohydrochloride

HRID 1939631
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1939631
[CH3:1][N:2]([CH3:26])[C:3]([CH:5]1[CH2:14][CH2:13][C:12]2[NH:11][C:10](=[O:15])[N:9]3[CH:16]=[C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[F:25])[N:18]=[C:8]3[C:7]=2[CH2:6]1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:33]>C(OCC)(=O)C>[ClH:33].[CH3:26][N:2]([CH2:3][CH:5]1[CH2:14][CH2:13][C:12]2[NH:11][C:10](=[O:15])[N:9]3[CH:16]=[C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[F:25])[N:18]=[C:8]3[C:7]=2[CH2:6]1)[CH3:1]
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Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 154342819-(N,N-Dimethylcarbamyl)-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-oneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 193675879-(N,N-Dimethylaminomethyl)-2-(2-fluoropenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one monohydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857
Ethyl Acetate
Lösungsmittel
2×

Versuchsvorschrift

To 100 mL of anhydrous tetrahydrofuron was added 9-(N,N-Dimethylcarbamyl)-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (70 mg). The mixture was refluxed until the solid had completely dissolved. Refluxing was ceased and 100 mg of lithium aluminum hydride was added to the solution. This mixture was allowed to stand for 20 min before being quenched with ethyl acetate. The quenched reaction mixture was filtered through celite and the solvent removed in vacuo to yield an oil. The oil was then dissolved in 5 mL of ethyl acetate and to this ethyl acetate solution was added 1 mL of HCl saturated ethyl acetate. A solid precipitated was collected and dried to yield 9-(N,N-Dimethylaminomethyl)-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one monohydrochloride (Compound 24), m.p.>325° C.

Aufarbeitung

  1. temperatureThe mixture was refluxed until the solid
  2. dissolutionhad completely dissolved
  3. temperatureRefluxing
  4. custombefore being quenched with ethyl acetate
  5. customThe quenched reaction mixture
  6. filtrationwas filtered through celite
  7. customthe solvent removed in vacuo
  8. customto yield an oil
  9. customA solid precipitated
  10. customwas collected
  11. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d391f3f8a9a447618d16c817944535c6
Quelldatensatz
uspto-grants-1997_12
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05696260

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