2-(6-(Cyanomethyl)pyridin-2-yl)acetonitrile → HCID 12131338, Verbindung

HRID 1939874Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1939874
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[N:5]=1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][NH2:12])[N:5]=1

Komponenten

4

Edukt 1

HCID 5826922-(6-(Cyanomethyl)pyridin-2-yl)acetonitrile

Produkt 1

HCID 12131338HCID 12131338, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2,6-bis(cyanomethyl)pyridine (4.3 g, 27 mmol) in methanol (75 ml, saturated with ammonia) was added Raney nickel (10.0 g, excess) and the mixture hydrogenated at 45 psi and room temperature for 48 hours. The catalyst was filtered off and the solvent evaporated in vacuo to give 2,6-bis(2-aminoethyl)pyridine as a brown viscous oil (3.7 g, 83%). This was used without further purification.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1ed6c26f3d85450ebdb7a193f29c0e46
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05698546

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