7-(Trifluoroacetylamino)-2,3-dihydrobenzofuran → 2,3-Dihydro-1-benzofuran-7-amine

HRID 1940592Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1940592
FC(F)(F)C([NH:5][C:6]1[C:14]2[O:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1)=O>CO.[OH-].[Na+]>[NH2:5][C:6]1[C:14]2[O:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

Komponenten

4

Edukt 1

HCID 214634927-(Trifluoroacetylamino)-2,3-dihydrobenzofuran

Produkt 1

HCID 128059502,3-Dihydro-1-benzofuran-7-amineAusbeute 96,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of 7-(trifluoroacetylamino)-2,3-dihydrobenzofuran (D2) (1.6 g) in methanol (30 ml) and 10% NaOH (3 ml) was heated to reflux for 24h. The mixture was evaporated under reduced pressure and partitioned between ethyl acetate and water. The organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to give the title compound (900 mg, 96%) as a pale orange oil, which crystallised on standing.

Aufarbeitung

  1. temperatureto reflux for 24h
  2. customThe mixture was evaporated under reduced pressure
  3. custompartitioned between ethyl acetate and water
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8a7f6292877d4ba6b73be4be91a8a92f
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05700818

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