Sodium Hydroxide → HCID 21463488, Verbindung

HRID 1940593Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1940593
[N+:1]([O-:4])([O-])=[O:2].[K+].[NH2:6][C:7]1[C:15]2[O:14][CH2:13][CH2:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[NH2:6][C:7]1[C:15]2[O:14][CH2:13][CH2:12][C:11]=2[CH:10]=[C:9]([N+:1]([O-:4])=[O:2])[CH:8]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 24434Potassium NitrateHCID 128059502,3-Dihydro-1-benzofuran-7-amine

Produkt 1

HCID 21463488HCID 21463488, VerbindungAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

Potassium nitrate (8.6 g) was added portionwise over 1/2 h to a solution of 7-amino-2,3-dihydrobenzofuran (D3) (10 g) in concentrated sulphuric acid (75 ml) at 5°-10° C. The resulting solution was stirred for a further 2 h, then added to ice, basified with 40% NaOH, and extracted into ethyl acetate. The organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to give the title compound (10.1 g, 76%) as a red/brown foam.

Aufarbeitung

  1. additionadded to ice
  2. extractionextracted into ethyl acetate
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-564bc4fed1db4bd58ced1f5f67e2190f
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05700818

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