N-Benzylglycine ethyl ester → N-benzyl-N-[3-(4,5,7-trifluorobenzothiazol-2-yl)propionyl]-glycine ethyl ester

Beteiligte Stoffe

Reaktionsschritte

To methylene chloride (10 ml) was added 3-(4,5,7-trifluorobenzothiazol-2-yl)propionic acid (522 mg, 2 mmol) obtained in Example 3-i), WSC.HCl (422 mg, 2.2 mmol) and N-benzylglycine ethyl ester (386 mg, 2 mmol) and the mixture was stirred for 15 hours at room temperature. The reaction mixture was washed with 7% hydrochloric acid and water successively. The organic layer was dried and evaporated. The resulting residue was purified on a silica gel column to give N-benzyl-N-[3-(4,5,7-trifluorobenzothiazol-2-yl)propionyl]-glycine ethyl ester (680 mg, 78%) as an oil.

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