Hydrochloric Acid → 4-[(Benzylamino)methyl]benzonitrile

HRID 1941099Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1941099
C([C:8](=[N:17]O)[C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.Cl>C(O)C>[CH2:8]([NH:17][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]#[N:14])=[CH:15][CH:16]=1)[C:9]1[CH:16]=[CH:15][CH:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86751769HCID 86751769, Verbindung

Produkt 1

HCID 123291374-[(Benzylamino)methyl]benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

3.44 g (15 mmol) of 4-(benzyloximinomethyl)benzonitrile in 120 ml of ethanol are cooled to -15° C. 4.46 g (48 mmol, 4.85 ml) of borane-pyridine complex are then added dropwise in the course of 10 minutes and then 26 ml of ethanolic HCl solution in the course of 20 minutes. After stirring at room temperature for 24 h, the resulting solid is filtered off, dissolved in dichloromethane and the solution is washed with water and sodium hydrogen carbonate solution. The organic phase is dried and concentrated in vacuo.

Aufarbeitung

  1. addition4.46 g (48 mmol, 4.85 ml) of borane-pyridine complex are then added dropwise in the course of 10 minutes
  2. customin the course of 20 minutes
  3. filtrationthe resulting solid is filtered off
  4. dissolutiondissolved in dichloromethane
  5. washthe solution is washed with water and sodium hydrogen carbonate solution
  6. customThe organic phase is dried
  7. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bb0550b839ee43c0a9551859d23e1f80
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05703050

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