Hydrochloric Acid → HCID 67503622, Verbindung

HRID 19415

Reaktionsgleichung

Reaktionsgleichung von HRID 19415
C(OC(=O)[NH:7][CH:8]([C:16](=[O:28])[NH:17][C:18]1[CH:22]=[CH:21][N:20]([CH2:23][C:24]([OH:27])([CH3:26])[CH3:25])[N:19]=1)[CH2:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)(C)(C)C.[ClH:30]>CO>[ClH:30].[NH2:7][CH:8]([CH2:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[C:16]([NH:17][C:18]1[CH:22]=[CH:21][N:20]([CH2:23][C:24]([OH:27])([CH3:25])[CH3:26])[N:19]=1)=[O:28]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66898741[1-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-ylcarbamoyl]-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid t-butyl ester

Produkt 1

HCID 67503622HCID 67503622, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of [1-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-ylcarbamoyl]-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid t-butyl ester (3.2 g, 7.8 mmol) in methanol (150 mL) was treated with hydrogen chloride gas for 2 min at 0° C. and then stirred at room temperature for 1 h. After this time the mixture was concentrated in vacuo and the residue treated with acetonitrile (50 mL). The mixture was concentrated in vacuo which afforded 2-amino-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-3-(tetrahydro-pyran-4-yl)-propionamide hydrochloride (3.0 g, 100%) as a white solid.

Aufarbeitung

  1. concentrationAfter this time the mixture was concentrated in vacuo
  2. additionthe residue treated with acetonitrile (50 mL)
  3. concentrationThe mixture was concentrated in vacuo which

Quellen und Nachweise

ORD-Eintrag
ord-9a703a7a4178498f8c275dbd4a58d637
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07741327B2

Verknüpfte Notizen

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