4-Methyl-1,2-oxazole-3-carboxylic acid → HCID 53241106, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[CH3:19][C:20]1[C:21]([C:25](O)=[O:26])=[N:22][O:23][CH:24]=1>>[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:14])([F:15])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:25]([C:21]3[C:20]([CH3:19])=[CH:24][O:23][N:22]=3)=[O:26])[CH:3]=[CH:4][C:5]=2[F:18])([CH3:17])[N:9]=1Komponenten
3
Versuchsvorschrift
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 4-methyl-isoxazole-3-carboxylic acid following procedure I yielded the title compound as a white solid. MS (ISP): m/z=369.2 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-0e16344e0a024f56852efedf64729c02
- Quelldatensatz
- uspto-grants-2013_03