4-Heptanol, 1,1,1,7,7,7-hexafluoro- → 1,1,1,7,7,7-Hexafluoro-4-heptanone

HRID 1942309Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1942309
[F:1][C:2]([F:14])([F:13])[CH2:3][CH2:4][CH:5]([OH:12])[CH2:6][CH2:7][C:8]([F:11])([F:10])[F:9].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[F:1][C:2]([F:13])([F:14])[CH2:3][CH2:4][C:5](=[O:12])[CH2:6][CH2:7][C:8]([F:10])([F:11])[F:9]

Komponenten

4

Edukt 2

HCID 538257994-Heptanol, 1,1,1,7,7,7-hexafluoro-HCID 178418287HCID 178418287, Verbindung2×

Produkt 1

HCID 5805611,1,1,7,7,7-Hexafluoro-4-heptanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1,1,1,7,7,7-Hexafluoroheptan-4-ol (1.4 g, 6.25 mmol) was dissolved in CH2Cl2 (12 mL) and pyridinium chlorochromate (PCC) (1.48 g, 6.87 mmol) was added. The mixture was stirred for 4 h. Additional PCC (800 mg) was added and the mixture stirred for 1 h. The mixture was filtered through celite and silica, washing with DCM. The resulting pale yellow solution was evaporated at room temperature to afford the title compound.

Aufarbeitung

  1. stirringthe mixture stirred for 1 h
  2. filtrationThe mixture was filtered through celite and silica
  3. washwashing with DCM
  4. customThe resulting pale yellow solution was evaporated at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-f3cbb7be50b041a6a8f31574d5bc39fc
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389547B2

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