Potassium Carbonate → N-(4-hydroxybutyl)benzothiazole-2-carboxamide

HRID 1942382Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1942382
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10](Cl)=[O:11].[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:10]([C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)=[O:11]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 258684-Amino-1-butanolHCID 2776254Benzothiazole-2-carbonyl chloride

Produkt 1

HCID 66937473N-(4-hydroxybutyl)benzothiazole-2-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

1 g (5 mmol) benzothiazol-2-carbonyl chloride, 542 mg (6 mmol) 4-aminobutan-1-ol and 1.4 g (10 mmol) K2CO3 in acetonitrile is stirred for three days at room temperature. The solvent is evaporated and the product is dissolved in ethyl acetate and washed with 2N HCl and water. After evaporation of the solvent the yellow semisolid is crystallized from ethyl acetate.

Aufarbeitung

  1. customThe solvent is evaporated
  2. dissolutionthe product is dissolved in ethyl acetate
  3. washwashed with 2N HCl and water
  4. customAfter evaporation of the solvent the yellow semisolid
  5. customis crystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-9ce5a60c887c4de9a7f58f32a483d012
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389555B2

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