Triethylamine → N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

HRID 1942388

Reaktionsgleichung

Reaktionsgleichung von HRID 1942388
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:16]([O:18][CH:19]([O:24][CH2:25][CH3:26])[CH2:20][CH2:21][CH2:22][NH2:23])[CH3:17].C(N(CC)CC)C.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[CH2:25]([O:24][CH:19]([O:18][CH2:16][CH3:17])[CH2:20][CH2:21][CH2:22][NH:23][C:13]([N:10]1[CH2:11][CH2:12][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][CH2:9]1)=[O:14])[CH3:26]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 10340Sodium CarbonateHCID 806724,4-DiethoxybutylamineHCID 866513114-Phenylpiperidine-1-carbonyl chloride

Produkt 1

HCID 66937642N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 895 mg (4 mmol) of 4-phenylpiperidine-1-carbonylchloride in 4 mL dichloromethane is added to 0.69 mL (4 mmol) 4,4-diethoxybutylamine and 1.68 mL (12 mmol) of triethylamine dissolved in 20 mL of dichloromethane. The mixture is stirred overnight. 20 mL of saturated sodium carbonate solution is added. The organic phase is separated, dried with sodium sulfate and the solvent evaporated.

Aufarbeitung

  1. customThe organic phase is separated
  2. dry with materialdried with sodium sulfate
  3. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-7751316ceb004643bc0cc65ccacf0998
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389555B2

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