Phenol → (2,2-Diethoxyethoxy)benzene

HRID 1942440

Reaktionsgleichung

Reaktionsgleichung von HRID 1942440
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12]Cl)[CH3:9].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>[OH-].[Na+].CN(C)C=O>[CH2:8]([O:10][CH:11]([O:14][CH2:15][CH3:16])[CH2:12][O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:9]

Komponenten

7

Edukt 4

HCID 996PhenolHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 121282-Chloro-1,1-diethoxyethane

Produkt 1

HCID 96328(2,2-Diethoxyethoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

0.94 g (10 mmol) of phenol, 1.52 g (10 mmol) of chloroacetaldehyde diethyl acetal, 2.77 g (20 mmol) of potassium carbonate, 500 mg of potassium iodide and 5 ml of dimethylformamide were heated for 1 hour at 175° C. under microwave conditions. The mixture was then diluted with 2M aqueous sodium hydroxide solution and extracted with dichloromethane. The organic layer was dried with sodium sulfate and the solvent evaporated in vacuum. The crude product was obtained in almost quantitative yield.

Aufarbeitung

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. customthe solvent evaporated in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-907d57b1e0434595b23a759968da1805
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389555B2

Verknüpfte Notizen

Wird geladen…