Isopropanol → HCID 58404446, Verbindung

HRID 1942583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1942583
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][CH:15]([OH:17])[CH3:16].[H-].[Na+]>O1CCCC1>[CH3:14][CH:15]([O:17][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11])[CH3:16]

Komponenten

5

Edukt 3

HCID 3776IsopropanolHCID 24758Sodium hydrideHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrile

Produkt 1

HCID 58404446HCID 58404446, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

To a solution of 4-fluoro-3-(trifluoromethyl)benzonitrile (10 g), i-PrOH (8.15 mL) in tetrahydrofuran (THF) (90 mL) stirred under nitrogen at −10° C. was added solid NaH (3.46 g) portionwise during 30 min. The reaction mixture was stirred at −10° C. for 6 h. The reaction mixture was quenched with water, partitioned between ether (100 mL) and water (50 mL). The organic phase was dried over magnesium sulphate and evaporated in vacuo to give the crude product 4-[(1-methylethyl)oxy]-3-(trifluoromethyl)benzonitrile (D10) (15 g).

Aufarbeitung

  1. customThe reaction mixture was quenched with water
  2. custompartitioned between ether (100 mL) and water (50 mL)
  3. dry with materialThe organic phase was dried over magnesium sulphate
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-012129b40fcc43a78051dac56f5f4c69
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389508B2

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