Trifluoroacetic acid → (R)-2-Amino-3-cyclohexylpropanoic acid trifluoroacetate

HRID 1943297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1943297
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C([NH:15][C@H:16]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:17]([OH:19])=[O:18])(OC(C)(C)C)=O>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[NH2:15][C@H:16]([CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[C:17]([OH:19])=[O:18]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 2755927(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-cyclohexylpropanoic acid

Produkt 1

HCID 68547671(R)-2-Amino-3-cyclohexylpropanoic acid trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5 ml of TFA were added to a solution of (R)-N-Boc-2-amino-3-cyclohexylpropanoic acid (3.0 g, 11.1 mmol) in 20 ml of CH2Cl2, and the mixture was stirred at RT overnight. After deprotection was complete, the CH2Cl2 was evaporated off, and the remaining solid was mixed with 50 ml of H2O and lyophilized. Yield: 2.84 g (90%) of (R)-2-amino-3-cyclohexylpropanoic acid trifluoroacetate as colorless solid.

Aufarbeitung

  1. customthe CH2Cl2 was evaporated off
  2. additionthe remaining solid was mixed with 50 ml of H2O

Quellen und Nachweise

ORD-Eintrag
ord-e1635b8dee454b27a6afff92f3283f61
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08389764B2

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