Hydrochloric Acid → Ethyl-3-iodomethyl-4-iodobutyrate
Reaktionsgleichung
[I:1][CH2:2][CH:3]([CH2:8][I:9])[CH2:4][C:5]([OH:7])=[O:6].Cl.[CH2:11](O)[CH3:12]>>[CH2:11]([O:6][C:5](=[O:7])[CH2:4][CH:3]([CH2:8][I:9])[CH2:2][I:1])[CH3:12]Komponenten
4
Versuchsvorschrift
A solution of 2.831 g (8 mmole) 3-iodomethyl-4-iodobutyric acid in 80 mL ethanol is saturated with HCl gas at 0° C. After stirring the solution at room temperature for two days, the solvent is removed under vacuum, and the residue is dissolved in dichloromethane. The dichloromethane layer is washed with 10% aqueous sodium bicarbonate (3×100 mL), water (1×100 mL) and brine. The separated dichloromethane layer is dried over with magnesium sulfate, filtered and evaporated to give ethyl-3-iodomethyl-4-iodobutyrate.
Aufarbeitung
- customthe solvent is removed under vacuum
- dissolutionthe residue is dissolved in dichloromethane
- washThe dichloromethane layer is washed with 10% aqueous sodium bicarbonate (3×100 mL), water (1×100 mL) and brine
- dry with materialThe separated dichloromethane layer is dried over with magnesium sulfate
- filtrationfiltered
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-1bd1c3cd8d8a456992990a9283a57020
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07744853B2
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