2,2-dimethyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine → HCID 66936725, Verbindung
Reaktionsgleichung
[CH3:1][C:2]1([CH3:12])[O:7][C:6]2[CH:8]=[CH:9][N:10]=[CH:11][C:5]=2[NH:4][CH2:3]1.[Br:13][C:14]1[CH:15]=[C:16]([CH:20]=[C:21]([Br:25])[C:22]=1[O:23][CH3:24])[C:17](Cl)=[O:18]>>[Br:13][C:14]1[CH:15]=[C:16]([C:17]([N:4]2[CH2:3][C:2]([CH3:12])([CH3:1])[O:7][C:6]3[CH:8]=[CH:9][N:10]=[CH:11][C:5]2=3)=[O:18])[CH:20]=[C:21]([Br:25])[C:22]=1[O:23][CH3:24]Komponenten
3
Versuchsvorschrift
By the same method as in the step d) of Example 2, 2,2-dimethyl-3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine (60 mg, 0.36 mmol) was reacted with 3,5-dibromo-4-methoxy-benzoyl chloride (120 mg, 0.36 mmol) to obtain the target compound, (3,5-dibromo-4-methoxy-phenyl)-(2,2-dimethyl-2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-methanone (73 mg, 44%).
Quellen und Nachweise
- ORD-Eintrag
- ord-352561afba39490d901ea3800ba77857
- Quelldatensatz
- uspto-grants-2013_03