HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetate → 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetate | HCID 175 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Phenol, o-mercapto-(6CI,7CI,8CI) | HCID 70718 | — |
| Edukt | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid | HCID 68494380 | — |
Reaktionsschritte
A solution of 4-(4-iodophenyl)butyric acid (0.86M) and dimethylformamide was treated with 2 eq of potassium carbonate, 1.5 eq of 2-hydroxythiophenol and a catalytic amount of cuperic acetate (0.01 eq). The reaction mixture was refluxed for 18 hr, cooled to 25 C, acidified with aqueous acid and extracted with ethyl acetate. The organic phase was concentrated. The residue was purified by flash chromatography using ethyl acetate/hexane as eluant to give 4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07744910B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-e7e01cb1d6b341e290203e4523dd3350 |
| Quellennotiz | uspto-grants-2010_06 |