Hydrochloric Acid → {5-Fluoro-3-[3-(4-fluorobenzenesulfonyl)pyridin-4-ylmethyl]-2-methylindol-1-yl}acetic acid

HRID 1944390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1944390
C[O:2][C:3](=[O:33])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C:7]([CH2:15][C:16]2[CH:21]=[CH:20][N:19]=[CH:18][C:17]=2[S:22]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:6]1[CH3:32].[OH-].[Na+].Cl>O1CCCC1>[F:14][C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][CH:11]=1)[N:5]([CH2:4][C:3]([OH:33])=[O:2])[C:6]([CH3:32])=[C:7]2[CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1[S:22]([C:25]1[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=1)(=[O:24])=[O:23]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67044123HCID 67044123, Verbindung

Produkt 1

HCID 42644619{5-Fluoro-3-[3-(4-fluorobenzenesulfonyl)pyridin-4-ylmethyl]-2-methylindol-1-yl}acetic acidAusbeute 46,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A mixture of {5-fluoro-3-[3-(4-fluorobenzenesulfonyl)pyridin-4-ylmethyl]-2-methylindol-1-yl}acetic acid methyl ester (0.21 g) and tetrahydrofuran (1.0 mL) was treated with 5.0 M aqueous sodium hydroxide solution (3.0 mL), and the resulting mixture was stirred at 40° C. for 3 hours. The mixture was acidified by the addition of 5.0 M aqueous hydrochloric acid solution and concentrated to low bulk under reduced pressure. The resulting precipitate was collected by filtration, washed with water and dried to afford the title compound as a white solid (0.094 g).

Aufarbeitung

  1. concentrationconcentrated to low bulk under reduced pressure
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5b9f3aa56e2c4ea6bfea9ae11f929d84
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394836B2

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