Hydrochloric Acid → [5-Fluoro-3-(4-phenylsulfonylpyridin-3-ylmethyl)-2-methylindol-1-yl]acetic acid

HRID 1944433

Reaktionsgleichung

Reaktionsgleichung von HRID 1944433
C[O:2][C:3](=[O:32])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C:7]([CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][C:21]=2[S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:6]1[CH3:31].[OH-].[Na+].Cl>O1CCCC1>[F:14][C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][CH:11]=1)[N:5]([CH2:4][C:3]([OH:32])=[O:2])[C:6]([CH3:31])=[C:7]2[CH2:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][C:21]=1[S:22]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)(=[O:24])=[O:23]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67044979[5-Fluoro-3-(4-phenylsulfonylpyridin-3-ylmethyl)-2-methylindol-1-yl]acetic acid methyl ester

Produkt 1

HCID 58201223[5-Fluoro-3-(4-phenylsulfonylpyridin-3-ylmethyl)-2-methylindol-1-yl]acetic acidAusbeute 81,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of [5-fluoro-3-(4-phenylsulfonylpyridin-3-ylmethyl)-2-methylindol-1-yl]acetic acid methyl ester (0.19 g) and tetrahydrofuran (1.0 mL) was treated with 2.0 M aqueous sodium hydroxide solution (3.0 mL), and the resulting mixture was stirred at room temperature for 3 hours. The mixture was acidified by the addition of 1.0 M aqueous hydrochloric acid solution, and the resulting precipitate was collected by filtration to afford the title compound as a pale yellow powder (0.15 g).

Aufarbeitung

  1. filtrationthe resulting precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-61ba05ee8450488181d93cd0ac46e568
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394836B2

Verknüpfte Notizen

Wird geladen…