Ethyl 6-chloro-4-hydroxy-3-quinolinecarboxylate → Ethyl 4,6-dichloroquinoline-3-carboxylate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Ethyl-6-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (19.8 mmol) and phosphorus (V) oxychloride (99.3 mmol) was stirred and heated to 125° C. for 12 hours. The mixture was cooled to ambient temperature and the phosphorus (V) oxychloride was evaporated. The crude product was used without further purification. MS m/z 271.80 (M+1).

Herkunft & Nachweise