Trifluoroacetic acid → HCID 59264546, Verbindung

HRID 1944717Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1944717
[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]([NH:12]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][C@H:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[NH2:12]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57791175HCID 57791175, Verbindung2×

Produkt 1

HCID 59264546HCID 59264546, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(R)-tert-Butyl 3-methoxy-1-phenylpropylcarbamate (Intermediate 61, 78 mg, 0.294 mmol) was dissolved in DCM (4.5 ml) and TFA (0.5 ml) was added. The reaction mixture was stirred for 1 h at room temperature when LCMS indicated that the reaction was complete. The reaction mixture was concentrated in vacuo, and the crude product was taken onto next step without further purification (0.294 mmol). LCMS [M+H]=166

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude product was taken onto next step without further purification (0.294 mmol)

Quellen und Nachweise

ORD-Eintrag
ord-d4c43da7970f4d3297495ebb8685d3c2
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394858B2

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