Potassium Carbonate → [4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, 1,1-dimethylethyl ester

HRID 1945187Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1945187
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([S:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH2:19][CH3:20])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH:3]=1.[C:21]([O:25][C:26](=[O:29])[CH2:27]Br)([CH3:24])([CH3:23])[CH3:22].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:27][C:26]([O:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:29])=[C:4]([S:9][C:10]2[CH:11]=[CH:12][C:13]([S:16]([CH2:19][CH3:20])(=[O:17])=[O:18])=[CH:14][CH:15]=2)[CH:3]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 669960804-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]-phenol

Produkt 1

HCID 86659304[4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, 1,1-dimethylethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of the product from step (iii) (0.3 g), tert-butylbromoacetate (0.15 ml) and potassium carbonate (0.13 g) in DMF (20 ml) was stirred at RT overnight. The mixture was partitioned between water and ethylacetate, the organics separated, dried, and evaporated under reduced pressure. Yield 0.55 g

Aufarbeitung

  1. customThe mixture was partitioned between water and ethylacetate
  2. customthe organics separated, dried
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bf0738449cd443e38942eb8572d0aff4
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394986B2

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