Potassium Carbonate → 2-(1,1-dimethylethyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-one

HRID 1946515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1946515
Br[C:2]1[C:3](=O)[CH2:4][CH2:5][CH2:6][C:7]=1[O:8]C.[CH3:11][C:12]([C:15]([NH2:17])=[NH:16])([CH3:14])[CH3:13].Cl.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.ClCCl>[CH3:11][C:12]([C:15]1[NH:17][C:3]2[CH2:4][CH2:5][CH2:6][C:7](=[O:8])[C:2]=2[N:16]=1)([CH3:14])[CH3:13]

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 2781880Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1)HCID 109981422-Bromo-3-methoxycyclohex-2-en-1-one

Produkt 1

HCID 584602242-(1,1-dimethylethyl)-1,5,6,7-tetrahydro-4H-benzimidazol-4-oneAusbeute 36,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a stirred solution of 2-bromo-3-(methyloxy)-2-cyclohexen-1-one (0.957 g) in anhydrous N,N-dimethylformamide (20 mL) at ambient temperature was added solid tert-butylcarbamidine hydrochloride (0.638 g) and potassium carbonate (1.613 g, 11.67 mmol). The reaction was then heated to 100° C. under an atmosphere of nitrogen for 2.5 h. The reaction was diluted with dichloromethane (50 mL) the resultant solid was removed by filtration. The filtrate was concentrated in vacuo. The sample was loaded in dichloromethane and purified on silica using a 0-25% methanol-dichloromethane gradient. The appropriate fractions were combined and evaporated in vacuo to give the required product (330 mg).

Aufarbeitung

  1. customwas removed by filtration
  2. concentrationThe filtrate was concentrated in vacuo
  3. custompurified on silica using a 0-25% methanol-dichloromethane gradient
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a19f9f4d950548c2bedbc31079e2d294
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399444B2

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