N-(2-methylpropyl)cyclopentanamine → N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclopentyl(isobutyl)amino]pyrimidine-4-carboxamide

HRID 1946754

Reaktionsgleichung

Reaktionsgleichung von HRID 1946754
[CH3:1][C:2]1[CH:7]=[C:6]([S:8](=[O:11])(=[O:10])[NH2:9])[CH:5]=[CH:4][C:3]=1[NH:12][C:13]([C:15]1[CH:20]=[C:19](Cl)[N:18]=[CH:17][N:16]=1)=[O:14].[CH:22]1([NH:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[NH2:9][S:8]([C:6]1[CH:5]=[CH:4][C:3]([NH:12][C:13]([C:15]2[CH:20]=[C:19]([N:27]([CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:28][CH:29]([CH3:31])[CH3:30])[N:18]=[CH:17][N:16]=2)=[O:14])=[C:2]([CH3:1])[CH:7]=1)(=[O:11])=[O:10]

Komponenten

3

Edukt 2

HCID 28428761N-(2-methylpropyl)cyclopentanamine2×HCID 594470566-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide2×

Produkt 1

HCID 25182906N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclopentyl(isobutyl)amino]pyrimidine-4-carboxamideAusbeute 80 %

Versuchsvorschrift

Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)-amide (Intermediate 17) and cyclopentyl-isobutyl-amine (Intermediate 27), the title compound was obtained as a white solid in 80% yield.

Quellen und Nachweise

ORD-Eintrag
ord-c19df2d7c12449fab918322b8cc518e6
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399448B2

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