N-Isopropylpropylamine → N-[4-(aminosulfonyl)-2-methylphenyl]-6-[isopropyl(propyl)amino]pyrimidine-4-carboxamide

HRID 1946756

Reaktionsgleichung

Reaktionsgleichung von HRID 1946756
[CH3:1][C:2]1[CH:7]=[C:6]([S:8](=[O:11])(=[O:10])[NH2:9])[CH:5]=[CH:4][C:3]=1[NH:12][C:13]([C:15]1[CH:20]=[C:19](Cl)[N:18]=[CH:17][N:16]=1)=[O:14].[CH2:22]([NH:25][CH:26]([CH3:28])[CH3:27])[CH2:23][CH3:24]>>[NH2:9][S:8]([C:6]1[CH:5]=[CH:4][C:3]([NH:12][C:13]([C:15]2[CH:20]=[C:19]([N:25]([CH:26]([CH3:28])[CH3:27])[CH2:22][CH2:23][CH3:24])[N:18]=[CH:17][N:16]=2)=[O:14])=[C:2]([CH3:1])[CH:7]=1)(=[O:11])=[O:10]

Komponenten

3

Edukt 2

HCID 89119N-IsopropylpropylamineHCID 594470566-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide2×

Produkt 1

HCID 25182908N-[4-(aminosulfonyl)-2-methylphenyl]-6-[isopropyl(propyl)amino]pyrimidine-4-carboxamide

Versuchsvorschrift

Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide (Intermediate 17) and propyl-isopropylamine (Matrix), the title compound was obtained as a white solid.

Quellen und Nachweise

ORD-Eintrag
ord-da86d518e5f949a9ac26f4b180ef861f
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399448B2

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