tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate → 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylic acid
Reaktionsgleichung
[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:16]([O:18]C(C)(C)C)=[O:17])[N:5]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[CH3:7]>CN1CCCC1=O>[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:16]([OH:18])=[O:17])[N:5]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:14])([CH3:15])[CH3:13])[C:6]=1[CH3:7]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 200 °C
Versuchsvorschrift
tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate (Intermediate 264, 100 mg) was dissolved in N-methylpyrrolidinone (10 ml), heated to 200° C. for 30 minutes. The resulting solution was carried on to the next step without further purification.
Aufarbeitung
- customThe resulting solution was carried on to the next step without further purification
Quellen und Nachweise
- ORD-Eintrag
- ord-447cf5db8bda49e8be118a8d969ff446
- Quelldatensatz
- uspto-grants-2013_03
- Patentnummer
- US08399489B2
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