Methanol → Methyl 6-fluoro-3-iodo-2-methylbenzoate

Reaktionsgleichung

C[Si](C=[N+]=[N-])(C)C.[F:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[C:13]([CH3:18])[C:12]([I:19])=[CH:11][CH:10]=1.[CH3:20]O>C1C=CC=CC=1>[F:8][C:9]1[C:14]([C:15]([O:17][CH3:20])=[O:16])=[C:13]([CH3:18])[C:12]([I:19])=[CH:11][CH:10]=1

Komponenten

Versuchsvorschrift

Trimethylsilyldiazomethane solution (2 M in Hexane) (18 mL, 35 mmol) was added dropwise to a stirred solution of the product of Step A (7.3 g, 33.2 mmol) in benzene containing 20% of methanol (total: 100 mL) at room temperature until solution retained a yellow color. The mixture was concentrated to remove the organic solvent. The remaining oil was poured over a silica gel plug in a 60-mL filter frit funnel and eluting with 200 mL of hexane containing 10% ethyl acetate. The filtrate was then concentrated to dryness to give the title compound as a bright yellow oil.