4-Piperidinecarboxylic acid → 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid

HRID 1949500

Reaktionsgleichung

Reaktionsgleichung von HRID 1949500
CS[C:3]1[S:4][CH2:5][C:6](=[O:8])[N:7]=1.[NH:9]1[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1>CO>[O:8]=[C:6]1[CH2:5][S:4][C:3]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)=[N:7]1

Komponenten

4

Edukt 2

HCID 37734-Piperidinecarboxylic acidHCID 14820222-(Methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one

Produkt 1

HCID 672406401-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-methylsulfanyl-thiazol-4-one (4.4 g, 30 mmol) in MeOH (60 mL) was added piperidine-4-carboxylic acid (3.9 g, 30 mmol). The mixture was stirred at room temperature for 16 hours. The resulting solid was collected by filtration, washed with fresh MeOH and dried to give the title compound.

Aufarbeitung

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with fresh MeOH
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-72f7a526c84c4e3faa7d653322bc5d49
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399681B2

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