4-Piperidinol, 1-methyl- → HCID 23087228, Verbindung

HRID 1950001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1950001
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

Komponenten

4

Edukt 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

Produkt 1

HCID 23087228HCID 23087228, Verbindung

Versuchsvorschrift

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

Aufarbeitung

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Quellen und Nachweise

ORD-Eintrag
ord-5180b8cb5d5d4ddfaf4ff088581d6be1
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08399520B2

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