Benzenamine, 3,5-bis(trifluoromethyl)- → Ethyl 4-(3,5-bis(trifluoromethyl)phenylamino)-6-methyl-2-(methylthio)pyrimidine-5-carboxylate

HRID 1950785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1950785
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]([S:14][CH3:15])[N:3]=1.[F:16][C:17]([F:30])([F:29])[C:18]1[CH:19]=[C:20]([CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:24]=1)[NH2:21]>>[F:16][C:17]([F:29])([F:30])[C:18]1[CH:19]=[C:20]([NH:21][C:2]2[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([CH3:13])[N:5]=[C:4]([S:14][CH3:15])[N:3]=2)[CH:22]=[C:23]([C:25]([F:26])([F:28])[F:27])[CH:24]=1

Komponenten

3

Edukt 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 22225416Ethyl 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine-5-carboxylate

Produkt 1

HCID 86658933Ethyl 4-(3,5-bis(trifluoromethyl)phenylamino)-6-methyl-2-(methylthio)pyrimidine-5-carboxylateAusbeute 71,7 %

Versuchsvorschrift

The title compound was prepared as described in Example 1d by starting from ethyl 4-chloro-6-methyl-2-(methyl thio)pyrimidine-5-carboxylate (1.2 g, 4.86 mmol) and 3,5-bis(trifluoromethyl)aniline (777 uL, 4.86 mmol) and continuing until the reaction yielded the brown solids, title compound ethyl 4-(3,5-bis(trifluoromethyl)phenylamino)-6-methyl-2-(methylthio)pyrimidine-5-carboxylate (1.53 g, 70.2%). MS m/z: 440.1 (M+1)+.

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-6b9c1fe165f948c6b44427a4bbb23663
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404677B2

Notizen zur Reaktion

Wird geladen…