Cyclopentanone → N-((1RS,2SR)-2-Cyclopentylamino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 1950960

Reaktionsgleichung

Reaktionsgleichung von HRID 1950960
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:24])[C:10]1[C:15]([S:16][CH3:17])=[CH:14][C:13]([C:18]([F:21])([F:20])[F:19])=[CH:12][C:11]=1[O:22][CH3:23].[C:25]1(=O)[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH:25]1([NH:1][CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]2[NH:8][C:9](=[O:24])[C:10]2[C:15]([S:16][CH3:17])=[CH:14][C:13]([C:18]([F:20])([F:21])[F:19])=[CH:12][C:11]=2[O:22][CH3:23])[CH2:29][CH2:28][CH2:27][CH2:26]1

Komponenten

3

Edukt 2

HCID 8452CyclopentanoneHCID 58062914cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2×

Produkt 1

HCID 51000675N-((1RS,2SR)-2-Cyclopentylamino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

Versuchsvorschrift

The title compound, light yellow solid, MS: m/e=431.3 [(M+H)+], was prepared in accordance with the general method of example 11 from cis-N-(2-amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate I) and cyclopentanone.

Quellen und Nachweise

ORD-Eintrag
ord-ad916108a9564759a807bb82aa426d25
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404673B2

Verknüpfte Notizen

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