Ethyl 4-isocyanatobutyrate → 4-{3-[4-Methyl-5-(2-morpholin-4-yl-pyridin-4-yl)-thiazol-2-yl]-ureido}-butyric acid ethyl ester
Reaktionsgleichung
C(OC(=O)C[CH2:6][NH:7][C:8]([NH:10][C:11]1[S:12][C:13]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:18]=2)=[C:14]([CH3:16])[N:15]=1)=[O:9])C.[CH2:30]([O:32][C:33](=[O:40])[CH2:34][CH2:35]CN=C=O)[CH3:31]>>[CH2:30]([O:32][C:33](=[O:40])[CH2:34][CH2:35][CH2:6][NH:7][C:8]([NH:10][C:11]1[S:12][C:13]([C:17]2[CH:22]=[CH:21][N:20]=[C:19]([N:23]3[CH2:24][CH2:25][O:26][CH2:27][CH2:28]3)[CH:18]=2)=[C:14]([CH3:16])[N:15]=1)=[O:9])[CH3:31]Komponenten
3
Versuchsvorschrift
The titled compound is prepared by an analogous procedure to 3-{3-[4-Methyl-5-(2-morpholin-4-yl-pyridin-4-yl)-thiazol-2-yl]-ureido}-propionic acid ethyl ester (Example 14) by replacing ethyl 3-isocyanatopropionate with 4-isocyanato-butyric acid ethyl ester.
Quellen und Nachweise
- ORD-Eintrag
- ord-278ad8c893564d7a9cfc4d5625cfb9c5
- Quelldatensatz
- uspto-grants-2013_03
- Patentnummer
- US08404684B2
Notizen zur Reaktion
Wird geladen…