Nicotinamidine hydrochloride → N-[4-Methyl-5-(2-pyridin-3-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

HRID 1951199

Reaktionsgleichung

Reaktionsgleichung von HRID 1951199
[CH3:1][C:2]1[N:3]=[C:4]([NH:19][C:20](=[O:22])[CH3:21])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9](N2CCOCC2)[N:8]=1.Cl.C(N)(=N)[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:19][C:20](=[O:22])[CH3:21])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[N:8]=1

Komponenten

3

Edukt 2

HCID 202042Nicotinamidine hydrochlorideHCID 86610334N-[4-Methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

Produkt 1

HCID 11415694N-[4-Methyl-5-(2-pyridin-3-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide

Versuchsvorschrift

The titled compound is prepared by an analogous procedure to N-[4-Methyl-5-(2-morpholin-4-yl-pyrimidin-4-yl)-thiazol-2-yl]-acetamide (25e) by replacing morpholinoformamidine hydrobromide (part 25c) with nicotinamidine hydrochloride.

Quellen und Nachweise

ORD-Eintrag
ord-82486817fdb842c9954f50ccb1a1b1a2
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404684B2

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