Hydrochloric Acid → 3-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

HRID 1951225Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1951225
C[O:2][C:3](=[O:20])[CH:4](C(OCC)=O)[CH2:5][C:6]1[S:7][C:8]([NH:11][C:12]([NH2:14])=[S:13])=[N:9][N:10]=1.Cl>[OH-].[Na+]>[NH:11]([C:8]1[S:7][C:6]([CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[N:10][N:9]=1)[C:12]([NH2:14])=[S:13]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86653060Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester

Produkt 1

HCID 866062213-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester (0.675 g, 2.91 mmol) is suspended in 2M NaOH (8 ml) and the reaction is stirred at reflux for 3.5 hours. When cool, the solution is acidified to pH 3 with 6M HCl and the titled compound is removed by filtration and dried.

Aufarbeitung

  1. temperatureat reflux for 3.5 hours
  2. temperatureWhen cool
  3. customthe titled compound is removed by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e963e179c2b34315ad0c3f3def9be1e2
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404684B2

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