1-(1,3-Benzothiazol-2-yl)propan-2-one → HCID 67017994, Verbindung

HRID 1951555

Reaktionsgleichung

Reaktionsgleichung von HRID 1951555
[CH:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[O:11][CH3:12])=O.[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[CH2:22][C:23]([CH3:25])=O.[NH2:26]/[C:27](/[CH3:31])=[CH:28]\[C:29]#[N:30]>C(O)(C)C>[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[C:22]1[CH:1]([C:3]2[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=2[O:11][CH3:12])[C:28]([C:29]#[N:30])=[C:27]([CH3:31])[NH:26][C:23]=1[CH3:25]

Komponenten

5

Edukt 3

HCID 3202941-(1,3-Benzothiazol-2-yl)propan-2-oneHCID 5325263(2Z)-3-Amino-2-butenenitrileHCID 166592514-Formyl-3-methoxybenzonitrile

Produkt 1

HCID 67017994HCID 67017994, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

150 mg (0.931 mmol) of the compound from example 3A, 178 mg (0.931 mmol) of 1-(1,3-benzo-thiazol-2-yl)acetone [Costa et al., J. Heterocycl. Chem. 28, 1541-1544 (1991)] and 76 mg (0.931 mmol) of 3-aminocrotononitrile are dissolved in 6 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator. The crude product obtained in this way is recrystallized from acetonitrile. 40 mg (11% of theory) of the title compound are obtained.

Aufarbeitung

  1. customthe volatile components are removed in a rotary evaporator
  2. customThe crude product obtained in this way
  3. customis recrystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-5a127e5df1cd4663b57cd001ba0bd306
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404723B2

Verknüpfte Notizen

Wird geladen…