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Sodium Bicarbonate → Benzyl 4-((2-amino-4-(5-bromo-4-(2-ethoxy-2-oxoethyl)thiophene-2-carbonyl)phenyl)ethynyl)benzoate

HRID 1952529
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Reaktionsgleichung

Reaktionsgleichung von HRID 1952529
[Br:1][C:2]1[S:6][C:5]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]#[C:16][C:17]3[CH:32]=[CH:31][C:20]([C:21]([O:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[O:22])=[CH:19][CH:18]=3)=[C:11]([N+:33]([O-])=O)[CH:10]=2)=[O:8])=[CH:4][C:3]=1[CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38].C([O-])(O)=O.[Na+]>CCOC(C)=O>[NH2:33][C:11]1[CH:10]=[C:9]([C:7]([C:5]2[S:6][C:2]([Br:1])=[C:3]([CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH:4]=2)=[O:8])[CH:14]=[CH:13][C:12]=1[C:15]#[C:16][C:17]1[CH:18]=[CH:19][C:20]([C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[O:22])=[CH:31][CH:32]=1
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Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 67496549Benzyl 4-((4-(5-bromo-4-(2-ethoxy-2-oxoethyl)thiophene-2-carbonyl)-2-nitrophenyl)ethynyl)benzoate

Produkt 1

HCID 67496516Benzyl 4-((2-amino-4-(5-bromo-4-(2-ethoxy-2-oxoethyl)thiophene-2-carbonyl)phenyl)ethynyl)benzoateAusbeute 105,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 3 (450 mg, 0.71 mmol) in EtOAc (10 mL) was added stannous chloride dihydrate (642 mg, 2.84 mmol). The resulting mixture was refluxed for one hour under N2. The reaction mixture was poured onto ice (5 g), and basified with saturated NaHCO3 solution to pH 8. The white milky mixture was filtered through a Celite pad to remove tin oxides. The organic layer from the filtrate was dried over MgSO4, filtered, and then concentrated in vacuo. MPLC purification (Hex:EtOAc/4:1) of the crude product gave the desired intermediate benzyl 4-((2-amino-4-(5-bromo-4-(2-ethoxy-2-oxoethyl)thiophene-2-carbonyl)phenyl)ethynyl)benzoate as a yellow foam (450 mg, 95%). 1H NMR (400 MHz, CDCl3) δ 8.07 (d, J=8.0 Hz, 2H), 7.60 (d, J=8.0 Hz, 2H), 7.51-7.36 (m, 7H), 7.22-7.18 (m, 2H), 5.38 (s, 2H), 4.18 (q, J=7.2 Hz, 2H), 3.64 (s, 2H), and 1.27 (t, J=7.2 Hz, 3H); 13C NMR (100 MHz, CDCl3) δ 186.72, 169.84, 166.01, 148.31, 143.21, 138.58, 136.12, 136.05, 135.39, 132.55, 131.71, 130.02, 129.98, 128.90, 128.62, 128.51, 127.71, 122.93, 118.70, 114.66, 111.47, 96.66, 88.41, 67.21, 61.63, 53.75, 35.32, and 14.44.

Aufarbeitung

  1. temperatureThe resulting mixture was refluxed for one hour under N2
  2. additionThe reaction mixture was poured onto ice (5 g)
  3. filtrationThe white milky mixture was filtered through a Celite pad
  4. customto remove tin oxides
  5. dry with materialThe organic layer from the filtrate was dried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customMPLC purification (Hex:EtOAc/4:1) of the crude product

Quellen und Nachweise

ORD-Eintrag
ord-1e5ea4f6d1d74be8984d3554cbe3037e
Quelldatensatz
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08404728B2

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