Nicotinic acid, hydrazide → 4-Allyl-1-nicotinoylsemicarbazide

HRID 1952757Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1952757
[CH2:1]([N:4]=[C:5]=[O:6])[CH:2]=[CH2:3].[C:7]([NH:15][NH2:16])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[N:10][CH:9]=1>CO>[CH2:1]([NH:4][C:5](=[O:6])[NH:16][NH:15][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[N:10][CH:9]=1)[CH:2]=[CH2:3]

Komponenten

4

Edukt 2

HCID 11112Nicotinic acid, hydrazideHCID 15123Allyl isocyanate

Produkt 1

HCID 233000284-Allyl-1-nicotinoylsemicarbazideAusbeute 92,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Allyl isocyanate (16.8 g) was added dropwise at ambient temperature to a stirred suspension of nicotinic hydrazide (25 g) in methanol (500 ml), then the mixture was stirred at ambient temperature for 2.75 hours, concentrated in vacuo to 250 ml, then diluted with ether (750 ml). The resulting solid was collected by filtration and dried in vacuo to give 4-allyl-1-nicotinoylsemicarbazide as a colourless solid (37.1 g), m.p. 165-167° C.

Aufarbeitung

  1. concentrationconcentrated in vacuo to 250 ml
  2. additiondiluted with ether (750 ml)
  3. filtrationThe resulting solid was collected by filtration
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d8394805a0c04a99a8da82ec32fa328d
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06114334

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