Lithium Bromide → (4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane

HRID 1953383Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953383
FC(F)(F)C(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])=[CH:9][CH:8]=1)=O.[Br-:23].[Li+]>C1COCC1.C(#N)C>[Si:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][Br:23])=[CH:8][CH:9]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]

Komponenten

5

Edukt 2

HCID 82050Lithium BromideHCID 99970054-{(t-Butyldimethylsilyl)oxy}benzyl trifluoroacetate

Produkt 1

HCID 10380115(4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilaneAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The benzyl trifluoroacetate 8 (17.9 g) was dissolved in dry THF, and dry lithium bromide (5.06 g) was added with stirring. The mixture was refluxed overnight, cooled, diluted with acetonitrile, and extracted three times with hexane. The hexane layers were combined, dried, filtered, and concentrated, thereby leaving the product 10 as a white oil in 88% yield.

Aufarbeitung

  1. temperatureThe mixture was refluxed overnight
  2. temperaturecooled
  3. extractionextracted three times with hexane
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-caea78892fa840b9b949dda17bcf4585
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06117845

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